The operating temperature range for the CN5000 SuperNIC is 0–55 °C (32–131 °F).

The operating temperature range for the CN5000 Switch and DCS switches is 5–40 °C (50–113 °F).

The ambient temperature is derated 1 °C for every 53 meters above 900 meters above sea level, or about 1.8 °F for every 174 feet above 2,953 feet above sea level. Operating humidity should be between 10% and 85% non-condensing.